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What is Celebrex 100 Mg ?
Celebrex is the brand name for the prescription pain reliever celecoxib, the drug’s active ingredient. Doctors prescribe Celebrex to treat pain, swelling, and stiffness of arthritis and some other conditions.
Celebrex is a non-steroidal anti-inflammatory drug, often referred to simply as an NSAID. NSAIDs block swelling, pain, and fever. Celebrex works by stopping the production of COX-2, a natural substance in the body that causes pain and inflammation. Celebrex is an NSAID and a COX-2 inhibitor.
The Food and Drug Administration (FDA) approved celecoxib in 1998 for the drug company G.D. Searle under the brand name Celebrex. In May 2014, the FDA approved the generic version of celecoxib.
Celebrex is indicated in adults for the symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
The decision to prescribe a selective cyclooxygenase-2 (COX-2) inhibitor should be based on an assessment of the individual patient’s overall risks.
As the cardiovascular (CV) risks of celecoxib may increase with dose and duration of exposure, the shortest duration possible and the lowest effective daily dose should be used. The patient’s need for symptomatic relief and response to therapy should be re-evaluated periodically, especially in patients with osteoarthritis.
Side Effects
Headache (10-16%)
Hypertension (13%)
Fever (9%)
Dyspepsia (8.8%)
Upper respiratory tract infection (8.1%)
Arthralgia (7%)
Cough (7%)
Vomiting (6%)
Diarrhea (5.6%)
Gastroesophageal reflux (5%)
Sinusitis (5%)
Abdominal pain (4.1%)
Nausea (3.5%)
Back pain (2.8%)
Insomnia (2.3%)
Pharyngitis (2.3%)
Flatulence (2.2%)
Rash (2.2%)
Dizziness (2%)
Peripheral edema (2%)
Anemia
Erythema multiforme
Exfoliative dermatitis
Hepatitis
Jaundice
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Drug Interactions
Celecoxib may increase the levels of lithium in your body. Signs of lithium toxicity include slurred speech and tremors.
Blood pressure drugs
Celecoxib may reduce the blood pressure-lowering effects of certain blood pressure drugs. Examples of these drugs include:
- antiotensin-converting enzyme (ACE) inhibitors
- angiotensin II receptor blockers
- diuretics
Transplant drug
Combining cyclosporine and celecoxib raises your risk of kidney damage.
Cancer drugs
Taking celecoxib with certain drugs used to treat cancer raises the risk of side effects from those drugs. These side effects include kidney damage and a decrease in cells that help you fight infection. Examples of these drugs include:
- methotrexate
- pemetrexed
Other NSAIDs
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). Combining it with other NSAIDs increases your risk of side effects. Examples of other NSAIDs include:
- ibuprofen
- naproxen
- aspirin
